Effect of Combination Therapy of Methotrexate with Vitamin A in Patients with Low Risk GTN (Gestational Trophoblastic Neoplasia)
@article{Ghasemian2018EffectOC, title={Effect of Combination Therapy of Methotrexate with Vitamin A in Patients with Low Risk GTN (Gestational Trophoblastic Neoplasia)}, author={Sedigheh Ghasemian and Z Karkhaneh Yousefi and Marjaneh Farazestanian and Leila Mousavi Seresht and Mohsen Foroughipour and Saeid Akhlaghi}, journal={Iranian Journal of Pharmaceutical Research : IJPR}, year={2018}, volume={17}, pages={38 - 42} }
Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the efficacy of combination therapy of Methotrexate with Vitamin A in low risk GTN treatment. This randomized clinical…Â
4 Citations
Evaluation of the Relation between Treatment Results and Predictive Factors in Metastatic and High Risk Gestational Trophoblastic Neoplasia
- Medicine
- 2019
The World Health Organization/International Federation of Gynecology and Obstetrics staging-scoring system is appropriate for gestational trophoblastic neoplasia management and the etoposide, methotrexate, actinomycin D, cyclophosphamide, and oncovin regimen showed superior efficacy.
Evaluation of High-Dose Vitamin A Treatment in Postmolar Patients with Low and Plateauing Serum Human Chorionic Gonadotropin Levels.
- MedicineRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia
- 2020
The limited use of HD Vit-A seems to have a safe and significant effect on the treatment of postmolar patients with low and plateauing serum human chorionic gonadotropin (hCG) levels and may decrease the development ofPostmolar GTN in this population.
Effect of Different Doses of Vitamin A on β-HCG Production in Patients Suffering from Gestational Trophoblastic Disease
- Medicine, Biology
- 2020
This study aimed to evaluate the effect of vitamin A doses (100,000 IU and 200,000IU) on the decrement of β-HCG levels in Gestational trophoblastic disease patients.
Efficacy of Oral Vitamin A in Reducing β-hCG Levels in Low-Risk Gestational Trophoblastic Neoplasia Patients
- MedicineAsian Pacific journal of cancer prevention : APJCP
- 2020
Oral administration of 6,000 IU vitamin A could help to reduce β-hCG levels in low-risk GTN patients who receive MTX chemotherapy, and the incidence of chemo resistance in the intervention group were lower than those in the control group.
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