Effect of Colchicine on Rat Blood Serum Xanthine Oxidase

@article{Affonso1962EffectOC,
  title={Effect of Colchicine on Rat Blood Serum Xanthine Oxidase},
  author={Ottilia R. Affonso and Emilio Mitidieri and G. G. Villela},
  journal={Nature},
  year={1962},
  volume={193},
  pages={64-64}
}
IN previous work1 it was shown that colchicine, when injected intraperitoneally, inhibits activities of rat liver xanthine oxidase and dehydrogenase. A strong inhibition was also observed when this drug was added in vitro to purified liver xanthine oxidase but statistically significant changes were not noted when colchicine was added to liver homogenate… CONTINUE READING