Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice.

Abstract

Transcriptional deregulation emerges as a key pathogenetic mechanism in ALS pathogenesis, and non-class-specific histone deacetylase (HDACs) inhibitors proved of therapeutic efficacy in preclinical models of ALS. When tested in patients, however, these drugs failed, probably because of a lack of selectivity toward pathogenetic HDACs. Here, we studied the… (More)
DOI: 10.1016/j.neulet.2017.07.033

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