Effect of Chronic Stress in the Onset of Parkinsons Disease: Possible Roleof Microglial Cells in Neuroinflammation

  title={Effect of Chronic Stress in the Onset of Parkinsons Disease: Possible Roleof Microglial Cells in Neuroinflammation},
  author={S. Sugama and B. Conti and Y. Kakinuma},
  journal={Journal of neurological disorders},
For many years, several studies have been conducted to investigate the effect of stress on the onset of Parkinson’s disease (PD), which is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). de Pablos et al. reported that stressed animals were associated with a higher rate of death of dopaminergic neurons in the substantia nigra, and that this effect was dependent on glucocorticoids 
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  • This article was originally published in a special issue, Microglia and Synaptic Reorganization handled by Editor(s). Dr. Hiroshi Nakanishi, Kyushu University, Japan Citation: Sugama S, Conti B, Kakinuma Y
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