Effect of Chronic Blockade of the Kallikrein-Kinin System on the Development of Hypertension in Rats.

@article{Rhaleb2001EffectOC,
  title={Effect of Chronic Blockade of the Kallikrein-Kinin System on the Development of Hypertension in Rats.},
  author={N. -E. Rhaleb and Xiao-Ping Yang and Masahiko Nanba and Edward G. Shesely and Oscar A. Carretero},
  journal={Hypertension},
  year={2001},
  volume={37 1},
  pages={121-128}
}
-The kallikrein-kininogen-kinin system is an important vasodilator and vasodepressor component of the cardiovascular system. Acting mainly through B(2) receptors, kinins may counterbalance the pressor effect of angiotensin II, salt, and mineralocorticoids plus salt. Using rats lacking the bradykinin precursors low- and high-molecular-weight kininogen or a B(2) kinin receptor antagonist (icatibant), we investigated whether absence or blockade of the kallikrein-kinin system alters blood pressure… CONTINUE READING

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Showing 1-10 of 51 references

Cardiovascular phenotype of male 129/SvEvTac, 129/SvJ and B2-KO mice.FASEB

  • Rhaleb N-E, Yang X-P, +5 authors OA Carretero
  • J. 2001;15:A101. Abstract
  • 2001

Effect of chronic blockade of the kallikrein-kinin system on the development of hypertension in rats

  • Rhaleb N-E, Yang X-P, M Nanba, EG Shesely, OA Carretero
  • Hypertension
  • 2001
2 Excerpts

in rats

  • HL Nolly, G Saed, G Scicli, OA Carretero, AG Scicli
  • 2001

? : evidence and confounding factors

  • Rhaleb N-E, Yang X-P, +5 authors OA Carretero
  • 1999

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