Effect of Chlorpromazine, Ether, and Phenobarbital on the Active-Phosphate Level of Rat Brain: an Improved Extraction Technique for Acid-soluble Phosphates

@article{Minard1962EffectOC,
  title={Effect of Chlorpromazine, Ether, and Phenobarbital on the Active-Phosphate Level of Rat Brain: an Improved Extraction Technique for Acid-soluble Phosphates},
  author={F. N. Minard and Raymond Davis},
  journal={Nature},
  year={1962},
  volume={193},
  pages={277-278}
}
DEPRESSANTS of cerebral activity have been reported to increase the level of adenosine triphosphate (ATP) and phosphocreatine (PC) in the brains of treated animals. This effect has been observed, for example, with barbiturates1,2 and chlorpromazine2 in rats and with reserpine in mice3. However, with the use of an improved extraction technique for nucleotides which prevents their degradation during isolation, we have been unable to confirm these observations. Furthermore, we have found an… CONTINUE READING