Effect of Casein Kinase 1α Activator Pyrvinium Pamoate on Erythrocyte Ion Channels

@article{Kucherenko2012EffectOC,
  title={Effect of Casein Kinase 1$\alpha$ Activator Pyrvinium Pamoate on Erythrocyte Ion Channels},
  author={Yuliya V. Kucherenko and Christine A. Zelenak and Matthias Eberhard and Syed M Qadri and Florian Lang},
  journal={Cellular Physiology and Biochemistry},
  year={2012},
  volume={30},
  pages={407 - 417}
}
Pharmacological modification of protein kinase CK1 (casein kinase 1) has previously been shown to influence suicidal erythrocyte death or eryptosis, which is triggered by activation of Cl<sup>-</sup>-sensitive Ca<sup>2+</sup>-permeable cation channels. Ca<sup>2+</sup> entering through those channels stimulates cell membrane scrambling and opens Ca<sup>2+</sup>-activated K<sup>+</sup>-channels resulting in KCl exit and thus cell shrinkage. The specific CK1-inhibitor D4476 (1 µM) blunted, whereas… 
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