Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models

@inproceedings{Liang2012EffectOC,
  title={Effect of Canagliflozin on Renal Threshold for Glucose, Glycemia, and Body Weight in Normal and Diabetic Animal Models},
  author={Yin Liang and Kenji Arakawa and Kiichiro Ueta and Yasuaki Matsushita and Chiaki Kuriyama and Tonya Martin and Fuyong Du and Yi Liu and June Zhi Xu and Bruce E Conway and Jamie Conway and David C Polidori and Kirk Ways and Keith T. Demarest},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Canagliflozin is a sodium glucose co-transporter (SGLT) 2 inhibitor in clinical development for the treatment of type 2 diabetes mellitus (T2DM). METHODS (14)C-alpha-methylglucoside uptake in Chinese hamster ovary-K cells expressing human, rat, or mouse SGLT2 or SGLT1; (3)H-2-deoxy-d-glucose uptake in L6 myoblasts; and 2-electrode voltage clamp recording of oocytes expressing human SGLT3 were analyzed. Graded glucose infusions were performed to determine rate of urinary glucose… CONTINUE READING

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Highly Influential
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