Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.

Abstract

To investigate the effect of calcium ions on the disintegration of enteric-coated dosage forms, disintegration testing was performed on enteric-coated aspirin tablets in the presence and absence of calcium in the test media. The results show that the presence of calcium ions retards the disintegration of enteric-coated dosage forms. This finding, which has not been reported in scientific literature, sheds light on the importance of conducting well-designed detailed investigations into the potential of calcium from dietary sources, calcium supplements, antacids, and/or phosphate binders affecting the absorption of drugs formulated into enteric-coated dosage forms. Moreover, it shows the necessity to investigate the potential of the occurrence of additional nutrient-excipient interactions.

DOI: 10.1002/jps.24700

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Cite this paper

@article{AlGousous2016EffectOC, title={Effect of Calcium Ions on the Disintegration of Enteric-Coated Solid Dosage Forms.}, author={Jozef Jawad Al-Gousous and Peter Langguth}, journal={Journal of pharmaceutical sciences}, year={2016}, volume={105 2}, pages={509-511} }