Effect of Ca2+ and salt on forms of estradiol cytoplasmic receptor in human neoplastic breast tissue.


After incubation with [3H]estradiol low-salt sucrose gradient centrifugation of 250 human breast tumor cytosis demonstrated receptor-bound steroid in both 4 S and 8 S forms. Cytosols prepared from 24 of these receptor-positive tumors were examined in the presence of KCl, Ca2+ and the serine protease inhibitor, phenylmethylsulfonyl fluoride. After incubation… (More)


  • Presentations referencing similar topics