Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part II

@article{Staatz2010EffectOC,
  title={Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part II},
  author={C. Staatz and L. Goodman and S. Tett},
  journal={Clinical Pharmacokinetics},
  year={2010},
  volume={49},
  pages={207-221}
}
  • C. Staatz, L. Goodman, S. Tett
  • Published 2010
  • Biology, Medicine
  • Clinical Pharmacokinetics
  • The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant drugs used for the prevention of organ rejection following transplantation. Both agents are metabolic substrates for cytochrome P450 (CYP) 3A enzymes — in particular, CYP3A4 and CYP3A5 — and are transported out of cells via P-glycoprotein (ABCB1). Several single nucleotide polymorphisms (SNPs) have been identified in the genes encoding for CYP3A4, CYP3A5 and P-glycoprotein, including CYP3A4 —392A>G… CONTINUE READING
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