Effect of CYP2C19 polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers.

@article{Lee2012EffectOC,
  title={Effect of CYP2C19 polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers.},
  author={Seunghwan Lee and Bo-Hyung Kim and Won-Seok Nam and Seo Hyun Yoon and Joo Youn Cho and S Shin and I. C. Jang and Kyung-Sang Yu},
  journal={Journal of clinical pharmacology},
  year={2012},
  volume={52 2},
  pages={195-203}
}
The current study assessed the influence of the CYP2C19 genotype on the pharmacokinetics and tolerability of voriconazole after single and multiple oral doses in healthy volunteers. Six subjects for the CYP2C19 homozygous extensive metabolizer (EMs), 6 for heterozygous extensive metabolizer (HEMs), and 6 for poor metabolizer (PMs) were enrolled, and their CYP2C9, CYP3A5, and MDR1 genotypes were analyzed. After a single intravenous infusion or single and multiple oral doses of 200 mg of… CONTINUE READING

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