Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients

  title={Effect of CYP2C19*17 gene variant on Helicobacter pylori eradication in peptic ulcer patients},
  author={Mateusz Kurzawski and Barbara Gawrońska-Szklarz and Joanna Wrześniewska and Andrzej Siuda and Teresa Starzyńska and Marek Droździk},
  journal={European Journal of Clinical Pharmacology},
Eradication of Helicobacter pylori is an important treatment strategy in peptic ulcer patients. Current regimens of eradication consist of proton pump inhibitor (PPI) and two antibiotics. The principal enzyme involved in PPIs metabolism is CYP2C19, which exhibits an interindividual variability of activity, mainly due to genetic polymorphism. Two alleles (CYP2C19*2 and CYP2C19*3), responsible for slow PPIs metabolism, were previously associated with higher efficacy of eradication. Recently, a… CONTINUE READING

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