Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae.

@article{Ostrander1998EffectOC,
  title={Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae.},
  author={Darin B. Ostrander and D. J. O'Brien and Jessica A. Gorman and George M Carman},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 30},
  pages={18992-9001}
}
CTP synthetase (EC 6.3.4.2, UTP:ammonia ligase (ADP-forming)) activity in Saccharomyces cerevisiae is allosterically regulated by CTP product inhibition. Amino acid residue Glu161 in the URA7-encoded and URA8-encoded CTP synthetases was identified as being involved in the regulation of these enzymes by CTP product inhibition. The specific activities of the URA7-encoded and URA8-encoded enzymes with a Glu161 --> Lys (E161K) mutation were 2-fold greater when compared with the wild-type enzymes… CONTINUE READING
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