Effect of CP101,606, a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor, on the volume of ischemic brain damage off cytotoxic brain edema after middle cerebral artery occlusion in the feline brain.

@article{Di1997EffectOC,
  title={Effect of CP101,606, a novel NR2B subunit antagonist of the N-methyl-D-aspartate receptor, on the volume of ischemic brain damage off cytotoxic brain edema after middle cerebral artery occlusion in the feline brain.},
  author={Xiao Di and R. R. Bullock and James C Watson and Panos P. Fatouros and Bertrand L Chenard and Fiona White and Frank D. Corwin},
  journal={Stroke},
  year={1997},
  volume={28 11},
  pages={2244-51}
}
BACKGROUND AND PURPOSE The purpose of this study was to test the hypothesis that the neuroprotective compound CP101,606 will ameliorate the increase in lactate, retard the development of cytotoxic edema, and decrease the infarct volume after ischemic stroke. METHODS Seventeen adult cats were allocated to control (n = 7) and CP101,606-treated groups (n = 10). Transorbital middle cerebral artery occlusion was performed under anesthesia. Extracellular fluid lactate by microdialysis as well as… CONTINUE READING

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