Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

  title={Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts},
  author={Lin Tan and Hui-Fu Wang and Meng-Shan Tan and Chen-Chen Tan and Xi-Chen Zhu and Dan Miao and Wan-Jiang Yu and Teng Jiang and Lan Tan and Jin-Tai Yu and Michael W Weiner and Paul S. Aisen and Ronald Petersen and Clifford R. Jack and William J. Jagust and John Q. Trojanowki and Arthur W. Toga and Laurel A Beckett and Robert C Green and Andrew J. Saykin and John C. Morris and Leslie M. Shaw and Jeffrey A. Kaye and Joseph F Quinn and Lisa C. Silbert and Betty Lind and Raina Carter and Sara Dolen and L. S. Schneider and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Bryan M. Spann and James Brewer and Helen Vanderswag and Judith L. Heidebrink and Joanne L. Lord and S. S. Mason and Colleen S. Albers and David S. Knopman and Karen Johnson and Rachelle Doody and Javier Villanueva-Meyer and Munir Chowdhury and Susan D. Rountree and Mimi Dang and Yaakov Stern and Lawrence S. Honig and Karen L. Bell and Beau M. Ances and Maria B. Carroll and Mary L. Creech and Erin E Franklin and Mark A. Mintun and Stacy Schneider and Angela Oliver and Daniel C. Marson and Randall G Griffith and David Glenn Clark and David Geldmacher and John C. Brockington and Erik D Roberson and Marissa Natelson Love and Hillel Z Grossman and Effie M. Mitsis and Raj C. Shah and Leyla deToledo-Morrell and Ranjan Duara and Daniel J. Varon and Maria T. Greig and Peggy Roberts and Marilyn S. Albert and Chiadi U. Onyike and Daniel D’Agostino and Stephanie A. Kielb and James E. Galvin and Brittany Cerbone and Christina A. Michel and Dana M. Pogorelec and Henry Rusinek and Mony J de Leon and Lidia Glodzik and Susan M De Santi and P. Murali Doraiswamy and Jeffrey R. Petrella and Salvador Borges-Neto and Terence Z. Wong and Edward Coleman and Charles D. Smith and Greg Jicha and Peter A. Hardy and Partha Sinha and Elizabeth Oates and Gary R. Conrad and Anton P. Porsteinsson and Bonnie S. Goldstein and Kim Martin and Kelly M. Makino and M. Saleem Ismail and Connie Brand and Ruth A. Mulnard and Gaby Thai and Catherine Mc-Adams-Ortiz and Kyle B. Womack and Dana Mathews and Mary Quiceno and Allan I. Levey and James J Lah and Janet S. Cellar and Jeffrey M. Burns and Russell Howard Swerdlow and William M. Brooks and Liana G. Apostolova and Kathleen D Tingus and Ellen Woo and Daniel H. S. Silverman and P. H. Lu and George Bartzokis and Neill R. Graff-Radford and Francine C Parfitt and Tracy Kendall and Heather P Johnson and Martin R. Farlow and Ann Marie Hake and Brandy R. Matthews and Jared R. Brosch and Scott Herring and Cynthia Hunt and Christopher H. van Dyck and Richard E. Carson and Martha G Macavoy and P C Rajath Varma and Howard M. Chertkow and Howard Bergman and Chris Hosein and Sandra E. Black and Bojana Stefanovic and Curtis Caldwell and Ging-Yuek R Hsiung and Howard Feldman and Benita Mudge and Michele Assaly and Elizabeth Finger and Stephen Pasternack and Irina Rachisky and Dick Trost and Andrew Kertesz and Charles Bernick and Donna Munic and M. Marcel Mesulam and Kristine Lipowski and Sandra Weintraub and Borna Bonakdarpour and Diana R. Kerwin and Chuang-Kuo Wu and Nancy Johnson and Carl H. Sadowsky and Teresa Villena and Raymond Scott Turner and Kathleen E. Johnson and Brigid A. Reynolds and Reisa A. Sperling and Keith A. Johnson and Gad A. Marshall and Jerome A Yesavage and Joy L. Taylor and Barton Lane and Allyson C. Rosen and Jared Tinklenberg and Marwan N. Sabbagh and Christine Belden and Sandra A. Jacobson and Sherye A. Sirrel and Neil W. Kowall and Ronald J. Killiany and Andrew E. Budson and Alexander Norbash and Patricia Lynn Johnson and Thomas O. Obisesan and Saba Wolday and Joanne S. Allard and Alan Lerner and Paula J Ogrocki and Curtis Tatsuoka and Parianne Fatica and Evan Fletcher and Pauline Maillard and John J Olichney and Charles DeCarli and Owen W Carmichael and Smita Kittur and Michael Borrie and T -Y Lee and Rob Bartha and Sterling C. Johnson and Sanjay Asthana and Cynthia M. Carlsson and Steven G. Potkin and Adrian Preda and Dana Nguyen and Pierre N. Tariot and Anna M Burke and Nadira Trncic and Adam Fleisher and Stephanie A Reeder and Vernice Bates and Horacio A Capote and Michelle M Rainka and Douglas W Scharre and Maria Kataki and Anahita Adeli and Earl A. Zimmerman and Dzintra F Celmins and Alice E. Brown and Godfrey D. Pearlson and Karen Blank and Karen S. Anderson and L. A. Flashman and Marc A. Seltzer and Mary L. Hynes and Robert B. Santulli and Kaycee M Sink and Leslie Gordineer and Jeff D. Williamson and Pradeep K Garg and F. J. Watkins and Brian R. Ott and Henry W. Querfurth and Geoffrey Tremont and Stephen P. Salloway and Paul Malloy and Stephen Correia and Howard J. Rosen and Bruce L. Miller and David C. Perry and Jacobo E. Mintzer and Kenneth M. Spicer and David M Bachman and Nunzio Pomara and Raymundo T. Hernando and Antero Sarrael and Norman Relkin and Gloria Chaing and Michael K. Lin and L D Ravdin and Amanda G. Smith and Balebail Ashok Raj and Kristin Fargher},
  booktitle={Scientific reports},
The Clusterin (CLU) gene, also known as apolipoprotein J (ApoJ), is currently the third most associated late-onset Alzheimer's disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD pathology in brain. Here, we evaluated the interaction between 7 CLU SNPs (covering 95% of genetic variations) and the role of CLU in β-amyloid (Aβ) deposition, AD-related structure atrophy, abnormal glucose metabolism on neuroimaging and CSF markers to clarify… CONTINUE READING