Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats.

@article{HimmsHagen1994EffectOC,
  title={Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats.},
  author={Jean Himms-Hagen and Jingying Cui and Elliot Danforth and Douglas J Taatjes and Sandra S. Lang and Brenda L. Waters and Thomas Harrison Claus},
  journal={The American journal of physiology},
  year={1994},
  volume={266 4 Pt 2},
  pages={
          R1371-82
        }
}
The objective was to assess the effect of a new, highly selective beta 3-adrenergic agonist, CL-316,243 (CL) (J. D. Bloom, M. D. Dutia, B. D. Johnson, A. Wissner, M. G. Burns, E. E. Largis, J. A. Dolan, and T. H. Claus., J. Med. Chem. 35: 3081, 1992), on energy balance and brown and white adipose tissues (BAT and WAT, respectively) in young rats eating a high-fat diet to induce obesity. Chronic treatment with CL increased body temperature and 24-h energy expenditure, mainly by increasing… CONTINUE READING
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