Effect of CGS 19755, a competitive N-methyl-D-aspartate antagonist, on general anesthetic potency.

  • L C Daniell
  • Published 1991 in Pharmacology, biochemistry, and behavior
CGS 19755 is a competitive N-methyl-D-aspartate (NMDA) receptor antagonist which penetrates the blood-brain barrier. The effect of pretreatment with subanesthetic doses of CGS 19755 on general anesthetic potency was determined in mice. Mice were pretreated with saline or CGS 19755 by intraperitoneal (IP) administration 30 min before IP administration of an… CONTINUE READING