Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis.

  title={Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis.},
  author={Maria Serena Longhi and Yun Ma and Ragai R. Mitry and Dimitrios P Bogdanos and Michael A. Heneghan and Paul Cheeseman and Giorgina Mieli-Vergani and Diego Vergani},
  journal={Journal of autoimmunity},
  volume={25 1},
BACKGROUND AND AIMS CD4 T lymphocytes constitutively expressing the IL-2-receptor alpha-chain (CD25) (T-regs) are central to self-tolerance maintenance, preventing the proliferation and effector function of autoreactive T-cells. In autoimmune hepatitis T-regs are defective in number but maintain the ability to suppress IFNgamma production by CD4+CD25- T-cells. We have studied the ability of CD4+CD25+ (T-regs) to regulate proliferation and cytokine production by CD8 T-cells in patients with… CONTINUE READING
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