Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis.

@article{ContopoulosIoannidis2003EffectOC,
  title={Effect of CCR5-delta32 heterozygosity on the risk of perinatal HIV-1 infection: a meta-analysis.},
  author={Despina Contopoulos-Ioannidis and Thomas R O'Brien and James J Goedert and Phillip S. Rosenberg and John P. A. Ioannidis},
  journal={Journal of acquired immune deficiency syndromes},
  year={2003},
  volume={32 1},
  pages={
          70-6
        }
}
Several studies have investigated whether heterozygosity for a 32-basepair deletion in the CC chemokine receptor 5 gene (CCR5-Delta32 ) affects susceptibility to perinatal HIV-1 infection, but results have been inconclusive. We performed a meta-analysis of published data from 11 studies of HIV-1 perinatally exposed children who were genotyped for the CCR5-Delta32 polymorphism. The crude overall HIV-1 infection rates, by simple data pooling, were 20% (one of five) amongCCR5-Delta32 homozygote… CONTINUE READING

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