Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis

@inproceedings{Liu2012EffectOC,
  title={Effect of CCR5-Δ32 Heterozygosity on HIV-1 Susceptibility: A Meta-Analysis},
  author={Sijie Liu and Chuijin Kong and Jie Wu and Hao Ying and Huanzhang Zhu},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility. METHODS We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were… CONTINUE READING

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