Effect of Botulinum Toxin and Surgery among Spasmodic Dysphonia Patients: A Systematic Review

@article{VanEsch2017EffectOB,
  title={Effect of Botulinum Toxin and Surgery among Spasmodic Dysphonia Patients: A Systematic Review},
  author={Babette Van Esch and Inge Wegner and Inge Stegeman and Wilko Grolman},
  journal={Otolaryngology–Head and Neck Surgery},
  year={2017},
  volume={156},
  pages={238 - 254}
}
Objective The effect of botulinum toxin among patients with adductor spasmodic dysphonia (AdSD) is temporary. To optimize long-term treatment outcome, other therapy options should be evaluated. Alternative treatment options for AdSD comprise several surgical treatments, such as thyroarytenoid myotomy, thyroplasty, selective laryngeal adductor denervation-reinnervation, laryngeal nerve crush, and recurrent laryngeal nerve resection. Here, we present the first systematic review comparing the… 

Figures and Tables from this paper

Adductor spasmodic dysphonia: Botulinum toxin a injections or laser thyroarytenoid myoneurectomy? A comparison from the patient perspective
TLDR
The long‐term results of endoscopic laser thyroarytenoid (TA) myoneurectomy versus BTX treatment in the same patients with AdSD are reported.
Non-aesthetic uses of botulinum toxin in the head and neck
TLDR
The range of uses for botulinum toxin in the head and neck has expanded enormously in recent years, with particular conditions focusing on dystonia, multiple system atrophy, migraines, facial nerve palsy, post-laryngectomy, cricopharyngeal dysphagia, Zenker’s diverticulum, retrograde cricophileal dysfunction disorder and sialorrhea.
Factors influencing long‐term treatment response to botulinum toxin injection for spasmodic dysphonia
The purpose of this study was to evaluate the outcomes of long‐term botulinum toxin type A (BoNTA) treatment for adductor spasmodic dysphonia (AdSD) and to determine the factors predictive of
Chemodenervation of the Larynx
TLDR
BoNT has been shown to be a useful and safe adjunct in the treatment for laryngeal disorders and may reduce or eliminate oral pharmacotherapy and/or prevent the need for a surgical intervention.
Post‐treatment clinical course following botulinum toxin injection therapy for adductor spasmodic dysphonia: Analysis of data from a placebo‐controlled, randomized, double‐blinded clinical trial in Japan
TLDR
The data from the placebo‐controlled, randomized, double‐blinded parallel‐group comparison/open‐label clinical trial of BT (Botox) to clarify the clinical factors that affect the therapeutic effect have been vague.
Quality of Life and Voice Changes After a Single Injection in Patients With ADSD Over Time.
Laryngeal Botulinum Toxin Injection for Vocal Tremor: Utility of Concurrent Strap Muscle Injection
TLDR
This work sought to describe the experience with thyroarytenoid and concurrent strap muscle injection with laryngeal botulinum toxin injections in patients with vocal tremor.
Methodological Quality of Systematic Reviews and Meta-analyses Published in High-Impact Otolaryngology Journals
TLDR
Intervention-focused systematic reviews and meta-analyses published in high-impact otolaryngology journals have important methodological limitations that diminish confidence in the results of these reviews.
Botulinum Neurotoxins as a Therapeutic
...
1
2
...

References

SHOWING 1-10 OF 49 REFERENCES
Surgery or Botulinum Toxin for Adductor Spasmodic Dysphonia: A Comparative Study
TLDR
The SLAD-R surgery for ADSD demonstrates outcomes equal to or superior to those of the current standard of Botox injections, and Objective voice ratings demonstrated similar levels of breathiness and overall voice quality in the treatment subgroups.
Outcomes Assessment following Treatment of Spasmodic Dysphonia with Botulinum Toxin
TLDR
Outcome measures justify the continued treatment of SD with BTX, which significantly lessened the patients' perception of dysphonia and improved their social functioning and their perception of their mental health.
Sporadic failure of botulinum toxin treatment in usually responsive patients with adductor spasmodic dysphonia
TLDR
The data suggest that treatment failure may occur regardless of the method of injection and of the drug preparation used, possibly due to mislocalisation of vocal folds.
Unilateral versus Bilateral Botulinum Toxin Injections in Adductor Spasmodic Dysphonia
TLDR
Most patients with adductor spasmodic dysphonia treated with percutaneous injections of botulinum toxin preferred the bilateral injection, in spite of more and longer-lasting side effects.
Current practices in the management of adductor spasmodic dysphonia.
TLDR
There is considerable variability in treatment practices for the management of ADSD with much variability with regard to starting injection dose, alternate treatments for ADSD, unilateral versus bilateral injections, and guidance technique.
The effect of patient factors on response outcomes to Botox treatment of spasmodic dysphonia.
Botulinum toxin injections for the treatment of spasmodic dysphonia.
TLDR
The evidence from randomized controlled trials does not allow firm conclusions to be drawn about the effectiveness of botulinum toxin for all types of spasmodic dysphonia, or for patients with different behavioral or clinical characteristics.
Selective Laryngeal Adductor Denervationreinnervation: A New Surgical Treatment for Adductor Spasmodic Dysphonia
TLDR
In this new procedure, the adductor branch of the recurrent laryngeal nerve is selectively denervated bilaterally, and its distal nerve stumps are reinnervated with branches of the ansa cervicalis nerve.
A comparison of the efficacy of unilateral versus bilateral botulinum toxin injections in the treatment of adductor spasmodic dysphonia.
TLDR
The hypothesis is that unilateral injections may reduce the severity of whisper voice and aspiration side effects in the early two to three weeks after treatment of adductor spasmodic dysphonia.
Factors influencing botulinum toxin dose instability in spasmodic dysphonia patients.
...
1
2
3
4
5
...