Effect of Bile Salts on Colonic Mucus Secretion in Isolated Vascularly Perfused Rat Colon

@article{Barcelo2001EffectOB,
  title={Effect of Bile Salts on Colonic Mucus Secretion in Isolated Vascularly Perfused Rat Colon},
  author={Aline Barcelo and Jean Claustre and F{\'e}rial Toumi and Ghislaine Burlet and J. -A. Chayvialle and J C Cuber and Pascale Plaisanci{\'e}},
  journal={Digestive Diseases and Sciences},
  year={2001},
  volume={46},
  pages={1223-1231}
}
Mainly composed of mucins, mucus secreted by goblet cells in the intestinal epithelium is critically involved in the protection of the gastrointestinal mucosa. The hypothesis that bile and some bile salts can induce mucus secretion was tested in the isolated perfused rat colon. Mucus release was evaluated using enzyme-linked immunosorbent assays and supported by histological analysis. Luminal administration of bile extract (1%) provoked mucus secretion in the rat colon. Deoxycholate (0.5–10 mM… CONTINUE READING

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