Effect of Baseline Breast Density on Breast Cancer Incidence, Stage, Mortality, and Screening Parameters: 25-Year Follow-up of a Swedish Mammographic Screening

@article{Chiu2010EffectOB,
  title={Effect of Baseline Breast Density on Breast Cancer Incidence, Stage, Mortality, and Screening Parameters: 25-Year Follow-up of a Swedish Mammographic Screening},
  author={Sherry Yueh-Hsia Chiu and Stephen W. Duffy and Amy Ming-Fang Yen and L{\'a}szl{\'o} K. Tab{\'a}r and Robert A. Smith and Hsiu-Hsi Chen},
  journal={Cancer Epidemiology, Biomarkers \& Prevention},
  year={2010},
  volume={19},
  pages={1219 - 1228}
}
Background: We aimed to quantitatively assess the effect of baseline breast density on the incidence, stage, and mortality, and also the natural course of the disease, considering the sensitivity of mammography to clarify its causal or masking effect. Methods: In total, 15,658 women ages 45 to 59 years from the Kopparberg randomized controlled trial in Sweden were prospectively followed from 1977 until 2004 to ascertain breast cancer incidence and death. Dense breast tissue collected at the… 
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149 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
9

149 Citations

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The association of breast density with breast cancer mortality in African American and white women screened in community practice
TLDR
The cumulative mortality probability estimates showed that women with dense breast tissues did not have significantly different breast cancer mortality than women with fatty breast tissue, regardless of age, and Aging, African American race, and advanced cancer stage were found to be significant risk factors for Breast cancer mortality.
Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study
TLDR
Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.
Mammographic density and structural features can individually and jointly contribute to breast cancer risk assessment in mammography screening: a case–control study
TLDR
It is suggested that the (relative) amount of fibroglandular tissue (density) and mammographic structural features (texture/parenchymal pattern) jointly can improve risk segregation of screening women, using information already available from normal screening routine, in respect to future personalized screening strategies.
Personalizing Mammography by Breast Density and Other Risk Factors for Breast Cancer: Analysis of Health Benefits and Cost-Effectiveness
TLDR
M mammography screening should be personalized on the basis of a woman's age, breast density, history of breast biopsy, family history of Breast Cancer Prevention, and beliefs about the potential benefit and harms of screening.
Breast density and breast cancer-specific survival by detection mode
TLDR
No clear association is apparent between breast density and breast cancer death, regardless of detection mode, and detection mode is strongly associated with breast cancerDeath.
A review of the influence of mammographic density on breast cancer clinical and pathological phenotype
TLDR
There is reasonable evidence to support positive relationships between high MD (HMD) and tumour size, lymph node positivity and local relapse in the absence of radiotherapy, but not between HMD and LVI, regional relapse or distant metastasis.
Relationship between mammographic density and breast cancer death in the Breast Cancer Surveillance Consortium.
TLDR
High mammographic breast density was not associated with risk of death from breast cancer or death from any cause after accounting for other patient and tumor characteristics, and risk factors for the development of breast cancer may not necessarily be the same as factors influencing the risk ofdeath after breast cancer has developed.
The influence of mammographic density on breast tumor characteristics
TLDR
PD does not seem to be differentially associated with tumor phenotype, except for tumor size, after taking mode of detection into consideration, in postmenopausal women.
Survival and Disease-Free Survival by Breast Density and Phenotype in Interval Breast Cancers
TLDR
The results support the advisability of routinely collecting information on breast density, both for further tailoring of screening strategies and as a prognostic factor for diagnosed breast cancers.
Breast density and mode of detection in relation to breast cancer specific survival: a cohort study
TLDR
High breast density at diagnosis may be associated with decreased breast cancer survival but breast density could not explain differences in survival according to detection mode.
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