Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats

@article{Tu2011EffectOB,
  title={Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats},
  author={Xian-kun Tu and Wei-zhong Yang and Ri-sheng Liang and Song-sheng Shi and Jian-ping Chen and Chun-mei Chen and Chun-Hua Wang and Hai-shu Xie and Yan Chen and Long-qiang Ouyang},
  journal={Neurochemical Research},
  year={2011},
  volume={36},
  pages={2022-2028}
}
Focal cerebral ischemia results in an increased expression of matrix metalloproteinase-9 (MMP-9), which induces vasogenic brain edema via disrupting the blood–brain barrier (BBB) integrity. Recent studies from our laboratory showed that baicalin reduces ischemic brain damage by inhibiting inflammatory reaction and neuronal apoptosis in a rat model of focal cerebral ischemia. In the present study, we first explored the effect of baicalin on the neuronal damage, brain edema and BBB permeability… CONTINUE READING

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