Effect of BRX‐220 against Peripheral Neuropathy and Insulin Resistance in Diabetic Rat Models

  title={Effect of BRX‐220 against Peripheral Neuropathy and Insulin Resistance in Diabetic Rat Models},
  author={M{\'a}ria K{\"u}rthy and Tam{\'a}s Mogyor{\'o}si and K{\'a}roly Nagy and Tibor Kukorelli and Andrea Jedn{\'a}kovits and L{\'a}szl{\'o} T{\'a}losi and Katalin B{\'i}r{\'o}},
  journal={Annals of the New York Academy of Sciences},
Abstract: Bimoclomol (BML), a symptomatic antidiabetic agent, has been developed by Biorex R & D Co. to treat diabetic neuropathy and retinopathy. BRX‐220, an orally active member of the BRX family, has been developed to treat diabetic complications and insulin resistance (IR) as a follow‐up compound. The effect of BRX‐220 on peripheral neuropathy was examined in rats with diabetes (type 1) induced by administration of a β‐cell toxin, streptozotocin (STZ, 45 mg/kg iv). Nerve functions were… 
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