Effect of BR-16A (Mentat), a polyherbal formulation on drug-induced catalepsy in mice.

  title={Effect of BR-16A (Mentat), a polyherbal formulation on drug-induced catalepsy in mice.},
  author={Anil Kumar and Srinivas K Kulkarni},
  journal={Indian journal of experimental biology},
  volume={44 1},
Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective loss of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). The events, which trigger and/or mediate the loss of nigral DA neurons, however, remain unclear. Neuroleptic-induced catalepsy has long been used as an animal model for screening drugs for Parkinsonism. Administration of haloperidol (1 mg/kg, ip) or reserpine (2 mg/kg, ip) significantly induced catalepsy in mice. BR-16A (50 and 100 mg… CONTINUE READING
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