Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.

@article{Mest1992EffectOB,
  title={Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.},
  author={H. Mest and T. Rein and A. Riedel and W. K{\"o}pernik and C. Braquet},
  journal={Agents and actions. Supplements},
  year={1992},
  volume={37},
  pages={
          228-34
        }
}
The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity. Esculetine or WEB 2170 antagonists of histamine and PAF, respectively and especially a combination of both can increase the threshold dose of ouabain-induced fibrillation demonstrating an antiarrhythmic effect. BN 52256 a substance with multi-antagonistic properties shows antiarrhythmic effect in this method, too. WEB 2170 and BN 52256… Expand

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TLDR
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The antiarrhythmic effect of BN 52021 appears to be related to an antagonism of an increase in slow calcium influx induced by PAF in myocardial cells, which can presumably prevent the re-entry mechanism involved in the development of ischemia-induced rhythm disturbances. Expand
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