Effect of BIBP3226 on inositol phosphate accumulation and cytosolic calcium level in control and NPY Y1 receptor expressing CHO-K1 cells.

@article{Vanderheyden1998EffectOB,
  title={Effect of BIBP3226 on inositol phosphate accumulation and cytosolic calcium level in control and NPY Y1 receptor expressing CHO-K1 cells.},
  author={Patrick M. L. Vanderheyden and Isabelle Van Liefde and J P Debacker and Guy Ebinger and Georges Vauquelin},
  journal={Regulatory peptides},
  year={1998},
  volume={75-76},
  pages={191-9}
}
BIBP3226 was developed as a potent, selective and competitive antagonist for NPY Y1 receptors by mimicking the C-terminal part of NPY. In agreement with previous studies, NPY mediated a pertussis toxin sensitive elevation of intracellular calcium concentration in CHO-K1 cells that express recombinant human NPY Y1 receptors which can be inhibited by BIBP3226. Surprisingly micromolar concentrations of BIBP3226 were found to induce by itself a fast increase of intracellular calcium concentration… CONTINUE READING