Effect of BCAA supplementation on central fatigue, energy metabolism substrate and muscle damage to the exercise: a systematic review with meta-analysis

  title={Effect of BCAA supplementation on central fatigue, energy metabolism substrate and muscle damage to the exercise: a systematic review with meta-analysis},
  author={Razie Hormoznejad and Ahmad Zare Javid and Anahita Mansoori},
  journal={Sport Sciences for Health},
Background and aims: Current state of evidence recommends beneficial effects of branched chain amino acids (BCAAs) on exercise performance; however, randomized controlled trials (RCTs) of BCAA supplementation yield discordant results. [] Key MethodMethods: A comprehensive search of PubMed, Embase, ISI web of science, and the Cochrane library has been conducted from inception to September 2016.

Does Branched-Chain Amino Acids (BCAAs) Supplementation Attenuate Muscle Damage Markers and Soreness after Resistance Exercise in Trained Males? A Meta-Analysis of Randomized Controlled Trials

Different outcomes for post-exercise responses may suggest that BCAAs supplementation can attenuate muscle damage and ameliorate muscle soreness after resistance exercise in trained males.

The effect of branched-chain amino acid on muscle damage markers and performance following strenuous exercise: a systematic review and meta-analysis.

Overall, BCAA reduced the level of muscle damage biomarkers and muscle soreness following muscle-damaging exercises, but the potential benefits of BCAA for muscle performance recovery is questionable and warrants further investigation.

Macronutrients and water – do they matter in the context of cognitive performance in athletes?

Proper nutrition is a key factor in physical performance, but there are also indications of an impact of dietary components on the brain function. Therefore, the aim of the study was to assess the

The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates

Nutritional consultancy based on the 4R’s is important for the wise stewardship of the hydration, feeding, and supplementation strategies to achieve a timely recovery.

Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise

Cannabidiol supplementation was unable to reduce fatigue, limit inflammation, or restore performance in well-trained female athletes.

Ketones for Post-exercise Recovery: Potential Applications and Mechanisms

This review will look at existing evidence on the role of ketones in recovery and attempt to identify the current best practices and potential mechanisms that drive improved recovery.

Prolonged Impairment of Short-Chain Fatty Acid and L-Isoleucine Biosynthesis in Gut Microbiome in Patients With COVID-19

Gut microbiome of COVID-19 patients displayed impaired capacity for SCFA and L-isoleucine biosynthesis which persisted even after disease resolution, underscoring the importance of gut microbial functions in SARS-CoV-2 infection pathogenesis and outcome.

Metabolic and Inorganic Elemental Profiling Analysis of Tortoise Shell for the Identification of Tortoise Strain

This study demonstrates that analyses of metabolites and inorganic elements contained in tortoise shell are useful to identify the strain of the tortoise.

A comparative study on the functional properties of mealworm (Tenebrio molitor) larvae and soybean protein isolates and hydrolysates

The present work aimed to compare the functional and antioxidant properties of mealworm larvae and soybean proteins at different processing steps. The mealworm larvae protein isolate (MPI) was

Oral Branched-Chain Amino Acids Supplementation in Athletes: A Systematic Review

Although BCAAs tended to activate anabolic signals, the benefits on performance and body composition were negligible, and most of the studies did not report the total protein intake across the day and the benefits of B CAAs should be interpreted with caution.



Effect of BCAA intake during endurance exercises on fatigue substances, muscle damage substances, and energy metabolism substances

Results indicate that supplementary BCAA decreased serum concentrations of the intramuscular enzymes as CK and LDH following exhaustive exercise, which suggests that BCAA supplementation may reduce the muscle damage associated with endurance exercise.

Effects of supplementation with branched chain amino acids and ornithine aspartate on plasma ammonia and central fatigue during exercise in healthy men.

Investigation of the effectiveness of oral BCAA + OA supplementation to reduce plasma ammonia concentration and enhance psychomotor performance during exhaustive exercise in healthy men found it a useful way to improve MCRT during high-intensity exercise and accelerate the elimination of ammonia at the recovery stage after exercise inhealthy young men.

Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study

It seems likely that BCAA provided greater bioavailablity of substrate to improve protein synthesis and thereby the extent of secondary muscle damage associated with strenuous resistance exercise is increased.

Effects of dietary leucine supplementation on exercise performance

Six weeks’ dietary leucine supplementation significantly improved endurance performance and upper body power in outrigger canoeists without significant change in the plasma ratio of tryptophan to BCAA.

Branched chain amino acids chronic treatment and muscular exercise performance in athletes: a study through plasma acetyl-carnitine levels

This work gives an interesting clue about the possibility to use acetyl-carnitine plasma levels to understand the biochemical importance of the BCAA as substrate able to influence physical performance, but further research is needed.

Effects of branched-chain amino acid supplementation on serum creatine kinase and lactate dehydrogenase after prolonged exercise.

Results indicate that supplementary BCAA decreased serum concentrations of the intramuscular enzymes CK and LDH following prolonged exercise, even when the recommended intake of BCAA was being consumed.

Carbohydrates, branched-chain amino acids, and endurance: the central fatigue hypothesis.

  • J. Davis
  • Biology
    International journal of sport nutrition
  • 1995
There is now convincing evidence that exercise-induced increases in the plasma free tryptophan (f-TRP)/branched-chain amino acids (BCCA) ratio are associated with increased brain 5-HT and the onset of fatigue during prolonged exercise.

Effect of Oral Branched-Chain Amino Acid Supplementation Prior to Resistance Exercise on Metabolic Hormones, Plasma Amino Acids, and Serum Indices of Muscle Damage in the Recovery Period

The results suggest that in resistance exercise, BCAAs may support an insulin-independent anabolic state, but it cannot prevent muscle damage.