Corpus ID: 24475186

Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.

@article{Bhanwra2000EffectOA,
  title={Effect of Azadirachta indica (Neem) leaf aqueous extract on paracetamol-induced liver damage in rats.},
  author={Sangeeta Bhanwra and J. Singh and Pratibha Khosla},
  journal={Indian journal of physiology and pharmacology},
  year={2000},
  volume={44 1},
  pages={
          64-8
        }
}
The effect of aqueous leaf extract of Azadirachta indica (A. indica) was evaluated in paracetamol induced hepatotoxicity in rats. Liver necrosis was produced by administering single dose of paracetamol (2 g/kg, p.o.). The liver damage was evidenced by elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Aqueous A. indica leaf extract (500 mg/kg, p.o… Expand
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References

SHOWING 1-10 OF 13 REFERENCES
Hepatoprotective activity of Azadirachta indica leaves on paracetamol induced hepatic damage in rats.
TLDR
It is stipulated that the extract treated group was protected from hepatic cell damage caused by paracetamol induction and the findings were further confirmed by histopathological study of liver. Expand
Possible mechanism of antiinflammatory activity of Azadirachta indica leaf extract
TLDR
The result suggests that A.indica extract's antiinflammatory effect may be due to antagonism of the deleterious effect of 5-HT and PGE1 on blood vessels. Expand
Effects of Azadirachta indica A Juss on some biochemical, immunological and visceral parameters in normal and stressed rats.
TLDR
In stressed rats, AI significantly attenuated the stress-induced suppression of humoral immune response and gastric ulcerogenesis and the possible mechanisms involved in the effects of AI in normal and stressful situations are discussed. Expand
ANTIDIABETIC AND ANTIHYPERGLYCAEMIC EFFECTS OF NEEM SEEDS KERNEL POWDER ON ALLOXAN DIABETIC RABBITS
Objective: To study the effects of neem kernel powder(NP) and glibenclamide. alone or in combination, on alloxan diabetic rats. Methods: The diabetic rabbits were given with NP alone or inExpand
Antidermatophytic activity of neem (Azadirachta indica) leaves in Vitro
TLDR
The ethanolic extract was found to be more active inhibiting 90% of the isolates at a concentration of 100 ug/ml while the MIC 50s and MIC 90s of the aqueous extract were 500 and > 500 uG/ml whereas the values for ketoconazole were 1 and 2.5 ug /ml respectively. Expand
Comparative evaluation of antiperoxidative action of silymarin and other flavonoids.
TLDR
It has been found that silymarin is about as active as quercet in and dihydroquercetin, and more active than quercitrin as antiperoxidative agent, irrespective to the system used for inducing peroxidation. Expand
[Experimental study of the effect of raw materials of the neem tree and neem extracts on dermatophytes, yeasts and molds].
TLDR
Neither the dried neem materials nor the medical preparations and oils had any effect on fungal growth; most of them were even contaminated with molds; some of the extracts showed antimycotic properties, which decreased with rising solvent polarity. Expand
Acetaminophen-induced oxidation of protein thiols. Contribution of impaired thiol-metabolizing enzymes and the breakdown of adenine nucleotides.
TLDR
The increase in activated oxygen species coupled with decreases in glutathione peroxidase and thioltransferase activity may be responsible in part for the increased levels of oxidized protein thiols observed following acetaminophen administration. Expand
Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2.
TLDR
The extensive APAP-oxidizing capacity of this hamster P450, designated P450IA2 based upon its similarity to rat P450d and rabbit form 4 in terms of NH2-terminal amino acid sequence, spectral characteristics, immunochemical properties, and inducibility by BNF, agrees with previous reports concerning the APAP substrate specificity of the rat and rabbit P 450IA2 proteins. Expand
Reactions of N-acetyl-p-benzoquinone imine with reduced glutathione, acetaminophen, and NADPH.
Synthetic N-acetyl-p-benzoquinone imine reacted with reduced glutathione (GSH), [14C]acetaminophen, and NADPH. It reacted rapidly with GSH to yield acetaminophen (33%) andExpand
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