Effect of Auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase

@article{Rigobello2005EffectOA,
  title={Effect of Auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase},
  author={Maria Pia Rigobello and Alessandra Folda and Maria Cristina Baldoin and Guido Scutari and Alberto Bindoli},
  journal={Free Radical Research},
  year={2005},
  volume={39},
  pages={687 - 695}
}
The mitochondrial production of hydrogen peroxide, in the presence of different respiratory substrates (succinate, glutamate, malate and isocitrate), is stimulated by submicromolar concentrations of auranofin, a highly specific inhibitor of thioredoxin reductase. This effect is particularly evident in the presence of antimycin. Auranofin was also able to unmask the production of hydrogen peroxide occurring in the presence of rotenone. However, at variance with whole mitochondria, auranofin does… Expand
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