Effect of Attenuation of Treg during BCG Immunization on Anti-Mycobacterial Th1 Responses and Protection against Mycobacterium tuberculosis

@article{Jaron2008EffectOA,
  title={Effect of Attenuation of Treg during BCG Immunization on Anti-Mycobacterial Th1 Responses and Protection against Mycobacterium tuberculosis},
  author={Barbara Jaron and Eddie Maranghi and Claude Leclerc and Laleh Majlessi},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={1554 - 1724}
}
BACKGROUND The functional equilibrium between natural regulatory T cells (Treg) and effector T cells can affect the issue of numerous infections. In unvaccinated mice, the influence of Treg in the control of primary infection with mycobacteria remains controversial. METHODOLOGY Here, we evaluated the role of Treg during prophylactic vaccination with Mycobacterium bovis BCG (Bacillus Calmette-Guérin) on the induction of T cell responses and on the protective effect against subsequent M… CONTINUE READING

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Regulatory T cells and infection: a dangerous necessity

Nature Reviews Immunology • 2007
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