Effect of Astrocaryum aculeatum (tucumã) on doxorubicin toxicity: in vivo experimental model Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo

Abstract

DOI http://dx.doi.org/10.1590/19820194201700036 Universidade Federal do Amapá, Macapá, AP, Brazil. Faculdade Estácio de Macapá, Macapá, AP, Brazil. Conflicts of interest: there are no conflicts of interest to declare. Abstract Objective: To obtain the oil of Astrocaryum aculeatum (A.a), and evaluate its genotoxicity/antigenotoxicity activities using the micronucleus test in peripheral blood cells. Methods: The oil of Astrocaryum aculeatum was obtained by hydraulic pressing. The animals used were healthy Swiss male mice, at 6-7 weeks of age; there were six per group. The genotoxic and antigenotoxic activity of concentrations were 500, 1,000 and 2,000 mg/kg per 0.5 mL (oral), followed or not followed by intraperitoneal injection of doxorubicin (0.3 mL-15 mg/kg by body weight), in addition to a negative group (water) and dimethyl sulfoxide (600 μL). Peripheral blood samples were collected 24h and 48h after treatment. Results: A statistically significant reduction was identified in the frequency of micronuclei in polychromatic cells ranging from 34.72% to 38.19% for 24-hour treatments, and from 63.70% to 66.12% for 48 hour. Conclusion: The fixed oil of tucumã presented antigenotoxic potential for the concentrations used in acute treatments.

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@inproceedings{Bruno2017EffectOA, title={Effect of Astrocaryum aculeatum (tucumã) on doxorubicin toxicity: in vivo experimental model Efeito da Astrocaryum aculeatum (Tucumã) na toxicidade da Doxorrubicina: modelo experimental in vivo}, author={Alan Bruno and Aur{\'e}lio Carneiro and Eduardo Abib Junior and S. A. Holanda Pinto and Ivagner Ferreira Ribeiro and Mayck Rian Gonçalves Magalh{\~a}es and Moacir de Azevedo and Bentes Monteiro Neto}, year={2017} }