Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet

@article{Kkgergin2009EffectOA,
  title={Effect of Artichoke Leaf Extract on Hepatic and Cardiac Oxidative Stress in Rats Fed on High Cholesterol Diet},
  author={Canan K{\"u}ç{\"u}kgergin and Abdurrahman Fatih Aydın and G{\"u}l {\"O}zdemirler-Erata and G{\"u}ldal Mehmetçik and N Koçak-Toker and M. Ozan Uysal},
  journal={Biological Trace Element Research},
  year={2009},
  volume={135},
  pages={264-274}
}
Hypercholesterolemia and lipid peroxidation play complementary roles in atherosclerosis. Artichoke (Cynara scolymus L., Asteraceae) leaf extract (ALE), rich in antioxidants, has cholesterol-reducing effect. We investigated the effect of ALE on serum and hepatic lipid levels and pro-oxidant–antioxidant balance in the liver and heart of hypercholesterolemic rats. Rats were fed on 4% (w/w) cholesterol and 1% cholic acid (w/w) supplemented diet for 1 month. ALE (1.5 g/kg/day) was given by gavage… CONTINUE READING
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