Corpus ID: 88652872

Effect of Antimalarial Drugs on Polymerization of Sickle Cell Hemoglobin (HbS)

@inproceedings{Chikezie2010EffectOA,
  title={Effect of Antimalarial Drugs on Polymerization of Sickle Cell Hemoglobin (HbS)},
  author={Paul Chidoka Chikezie and Chinwendu Maureen Chikezie and Patrick Ikechukwu Amaragbulem},
  year={2010}
}
Aim and Method: The effect of antimalarial drugs (Coartem TM , Quinine, and Chloroquine phosphate) on polymerization of sickle cell hemoglobin (HbS) was studied spectrophotometrically using hemolysates of HbS containing erythrocytes treated with sodium metabisulphite in the presence of each antimalarial drug. Results: Each drug caused significant (p<0.05) reduction in HbS polymerization: Coartem TM (17.05-31.07 %), Quinine (13.95-28.85 %) and Chloroquine phosphate (10.85-33.01 %). Conclusion… CONTINUE READING

Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

Figures and Tables from this paper.

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 22 REFERENCES

Proximate composition and in - vitro anti sickling property of Nigerian Cyperus esculentus ( tiger nut sedge )

  • CC Monago, AA Uwakwe
  • Trees for Life Journal
  • 2009

Proximate composition and in-vitro anti sickling property of Nigerian Cyperus esculentus (tiger nut sedge). Trees for Life Journal

  • CC Monago, AA Uwakwe
  • www. TFLJournal.org. September
  • 2009
VIEW 1 EXCERPT