Effect of Ammonia on Brain Serotonin Metabolism in Relation to Function in the Portacaval Shunted Rat

@article{Bergeron1990EffectOA,
  title={Effect of Ammonia on Brain Serotonin Metabolism in Relation to Function in the Portacaval Shunted Rat},
  author={Marcelle Bergeron and Margaret S. Swain and Tom{\'a}s A. Reader and Louise Grondin and Roger F. Butterworth},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={55}
}
Abstract: Four weeks following portacaval anastomosis (PCA) in the rat, severe liver atrophy, sustained hyperammonemia, and increased plasma and brain tryptophan are observed. Administration of ammonium acetate (NH4Ac) to rats with PCA precipitates severe signs of hepatic encephalopathy (HE) (loss of righting reflex progressing to loss of consciousness and ultimately deep coma). To evaluate the relationship between the deterioration of neurological status in HE and serotonin (5‐HT) metabolism… 
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Chapter 28 Trace amines in hepatic encephalopathy
Publisher Summary This chapter presents various studies to support a hypothesis given by Fischer and Baldessarini that hepatic encephalopathy (HE), a neuropsychiatric syndrome associated with hepatic
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