Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan

@inproceedings{Huang2016EffectOA,
  title={Effect of Alzheimer's Disease Risk Variant rs3824968 at SORL1 on Regional Gray Matter Volume and Age-Related Interaction in Adult Lifespan},
  author={Chu-Chung Huang and M T Liu and Hung-Wen Kao and Kun-Hsien Chou and Albert C. Yang and Ying-Hsiu Wang and Tong-Ru Chen and Shih-Jen Tsai and Ching-Po Lin},
  booktitle={Scientific reports},
  year={2016}
}
Sortilin receptor 1 (SORL1) is involved in cellular trafficking of amyloid precursor protein and plays an essential role in amyloid-beta peptide generation in Alzheimer disease (AD). The major A allele in a SORL1 single nucleotide polymorphism (SNP), rs3824968, is associated with an increased AD risk. However, the role of SORL1 rs3824968 in the normal ageing process has rarely been examined in relation to brain structural morphology. This study investigated the association between SORL1… CONTINUE READING
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