Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial

@article{Hajheydari2014EffectOA,
  title={Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial},
  author={Zohreh Hajheydari and Majid Saeedi and Katayoun Morteza-Semnani and Aida Soltani},
  journal={Journal of Dermatological Treatment},
  year={2014},
  volume={25},
  pages={123 - 129}
}
BACKGROUND Topical retinoids are considered first-line therapy in the treatment of acne vulgaris, yet can be associated with cutaneous irritations. [] Key MethodMATERIAL AND METHODS The randomized, double-blind, prospective 8-week trial evaluated inflammatory and non-inflammatory lesion scores and tolerability in 60 subjects with mild to moderate acne vulgaris (global acne grading system scale).
View on Taylor & Francis
dr-jetskeultee.nl
40 Citations
Background Citations
9
Methods Citations
1

40 Citations

Comparison of Topical Herbal Cream and 1% Clindamycin Gel for Treatment of Mild-to-moderate Acne: A Randomized Clinical Trial

The use of the herbal cream could be recommended for treating acne lesions due to few complications, greater patient satisfaction, and avoiding microbial resistance to chemical antimicrobials.

Comparison of topical 5% nicotinamid gel versus 2% clindamycin gel in the treatment of the mild-moderate acne vulgaris: A double-blinded randomized clinical trial

Five percent nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris and no side effect was observed during the treatment.

The effect of Unani antiacne formulation (Zimade Muhasa) on acne vulgaris: A single-blind, randomized, controlled clinical trial

The test formulation was well-tolerated and equivalent to 5% benzoyl peroxide in alleviating acne lesions and was also more effectual concerning the effects over scars, post inflammatory hyperpigmentation and fairness.

Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne

It is suggested that the new non-drug combined therapy significantly improved acne, which provided experimental evidence and treatment guidance for patients with mild to severe acne, especially patients with moderate acne.

The Role of Herbal Medicine in the Treatment of Acne Vulgaris: A Systematic Review of Clinical Trials

Evidence is provided that medicinal plants and phytochemicals are promising treatments for mild to moderate acne vulgaris, however, more quality of evidence and standardized methodologies are needed to support their effectiveness and safety claims.

A DOUBLE BLIND STUDY TO COMPARE THE EFFICACY OF ALOE VERA GEL AND UNDECYLENOYL PHENYLALANINE 2% FOR TREATMENT OF MELASMA

Undecylenoyl phenylalanine may represent an efficious and beneficial therapy of melasma and herbal agents which contain Aloe vera and falsely claim that they are effective should be discouraged to treat melasma.

Spironolactone loaded nanostructured lipid carrier gel for effective treatment of mild and moderate acne vulgaris: A randomized, double-blind, prospective trial.

Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract

An anti-acne hydrogel containing a combination of mangosteen rinds, aloe vera gel, and green tea–leaf extracts was superior to 1% clindamycin gel in antiacne and antiblotch activities when measured by TALs and erythema and melanin values.

International Journal of Clinical & Experimental Dermatology Acne Vulgaris: Pimples No Not Have Simple Solution

Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles.

A Comprehensive Review of Acne Vulgaris

Age, in particular, has a significant and well-known impact, as sebum levels are usually low in childhood, rise in the middle-to-late teen years, and remain stable into the seventh and eighth decades until endogenous androgen synthesis dwindles.

References

SHOWING 1-10 OF 30 REFERENCES

Comparison of topical 5% nicotinamid gel versus 2% clindamycin gel in the treatment of the mild-moderate acne vulgaris: A double-blinded randomized clinical trial

Five percent nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris and no side effect was observed during the treatment.

Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial

The 5% spironolactone topical gel resulted in a decrease in the TLC in acne vulgaris, while it had no significant efficacy in the ASI.

Double-blind, vehicle-controlled, multicenter comparison of two 0.025% tretinoin creams in patients with acne vulgaris.

Clinical trials of ayurvedic formulations in the treatment of acne vulgaris.

Two randomized, double-blind, controlled trials of 2219 subjects to compare the combination clindamycin/tretinoin hydrogel with each agent alone and vehicle for the treatment of acne vulgaris.

Topical tretinoin in acne therapy.

  • G. Webster
  • Medicine
    Journal of the American Academy of Dermatology
  • 1998

The treatment of atopic dermatitis with licorice gel

The results showed that licorice extract could be considered as an effective agent for treatment of atopic dermatitis.

Use of topical tretinoin and the development of noncutaneous adverse events: evidence from a systematic review of the literature.

Aloe vera: a systematic review of its clinical effectiveness.

  • B. VoglerE. Ernst
  • Medicine
    The British journal of general practice : the journal of the Royal College of General Practitioners
  • 1999
Oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidaemia and topical application is not an effective preventative for radiation-induced injuries.

Therapeutic agents and herbs in topical application for acne treatment

The topical application of therapeutic agents has been found to be more feasible than hormonal treatment and laser therapy, and herbs and naturally derived compounds have received considerable interest as they have fewer adverse effects than synthetic agents.