Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells.

@article{Hwang2009EffectOA,
  title={Effect of Akt overexpression on programmed cell death in antibody-producing Chinese hamster ovary cells.},
  author={Sun Ok Hwang and Gyun Min Lee},
  journal={Journal of biotechnology},
  year={2009},
  volume={139 1},
  pages={89-94}
}
Upon nutrient deprivation, Chinese hamster ovary (CHO) cells are subjected to two types of programmed cell death, apoptosis and autophagy. CHO cell engineering, as a means to improve foreign protein production, has focused mainly on anti-apoptosis. In this study, to determine the effect of Akt, which is known to regulate both apoptosis and autophagy, on… CONTINUE READING