Effect of Airway Pressure Release Ventilation on Dynamic Alveolar Heterogeneity.

@article{KollischSingule2016EffectOA,
  title={Effect of Airway Pressure Release Ventilation on Dynamic Alveolar Heterogeneity.},
  author={Michaela Kollisch-Singule and Sumeet Jain and Penny L Andrews and Bradford J. Smith and Katharine L Hamlington-Smith and Shreyas Roy and David Michael DiStefano and Emily Taylor Nuss and Josh Satalin and Qinghe Meng and William F. Marx and Jason H. T. Bates and Louis Albert Gatto and Gary F. Nieman and Nader M. Habashi},
  journal={JAMA surgery},
  year={2016},
  volume={151 1},
  pages={
          64-72
        }
}
IMPORTANCE Ventilator-induced lung injury may arise from heterogeneous lung microanatomy, whereby some alveoli remain collapsed throughout the breath cycle while their more compliant or surfactant-replete neighbors become overdistended, and this is called dynamic alveolar heterogeneity. OBJECTIVE To determine how dynamic alveolar heterogeneity is influenced by 2 modes of mechanical ventilation: low tidal-volume ventilation (LTVV) and airway pressure release ventilation (APRV), using in vivo… CONTINUE READING
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