Effect of Aculeacin A, a Wall‐Active Antibiotic, on Synthesis of the Yeast Cell Wall

@article{Yamaguchi1985EffectOA,
  title={Effect of Aculeacin A, a Wall‐Active Antibiotic, on Synthesis of the Yeast Cell Wall},
  author={Hideyo Yamaguchi and Tamio Hiratani and Misuzu Baba and Masako Osumi},
  journal={Microbiology and Immunology},
  year={1985},
  volume={29}
}
A wall‐active, amphophilic antibiotic aculeacin A significantly but incompletely inhibited in vitro the activity of β‐(1,3)glucan synthase prepared from highly susceptible yeasts Saccharomyces cerevisiae and Candida albicans. In contrast, comparable cell‐free preparations from S. cerevisiae active in chitin synthase or mannan synthase were insensitive to the antibiotic, suggesting selectivity of its action in synthesis of the yeast cell wall. 
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TLDR
The mode of action of a new antifungal antibiotic, aculeacin A, was studied with the cells of Saccharomyces cerevisiae, and the distinct decrease of viable cells was observed.
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TLDR
The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity, and has relatively low toxicity in mice.
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TLDR
Six new antibiotics were isolated as the minor components related to aculeacin A from the culture broth of Aspergillus aculeatus M-4214 and named as aculeacs B, C, D, E, F and G and they showed significant activity against fungi.
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TLDR
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TLDR
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TLDR
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TLDR
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Addition of the antifungal antibiotic papulacandin B to an exponential culture of Geotrichum lactis inhibited incorporation of glucose into the alkali-insoluble and alkali-soluble glucan fractions of
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