Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.

@article{Lynx2008EffectOA,
  title={Effect of AZT on thymidine phosphorylation in cultured H9c2, U-937, and Raji cell lines.},
  author={Matthew David Lynx and Bae-Kwang Kang and E. E. Mckee},
  journal={Biochemical pharmacology},
  year={2008},
  volume={75 8},
  pages={
          1610-5
        }
}
3'-azido-3'-deoxythymidine (AZT) has been shown to be a potent inhibitor of thymidine kinase 2 in work from this laboratory. Inhibition results in decreased salvage of thymidine to TTP, which may lead to depletion of the TTP pool and result in the mitochondrial dysfunction and mt-DNA depletion observed with AZT toxicity. The effect of AZT on thymidine phosphorylation in growing cells expressing thymidine kinase 1 has not been shown. Three cell lines were used in these experiments: H9c2, derived… CONTINUE READING
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