Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents

  title={Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents},
  author={David N Sheppard and Michael J. Welsh},
  journal={The Journal of General Physiology},
  pages={573 - 591}
The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl- channel that is regulated by cAMP-dependent phosphorylation and by intracellular ATP. Intracellular ATP also regulates a class of K+ channels that have a distinct pharmacology: they are inhibited by sulfonylureas and activated by a novel class of drugs called K+ channel openers. In search of modulators of CFTR Cl- channels, we examined the effect of sulfonylureas and K+ channel openers on CFTR Cl- currents in cells… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 39 references

Identification and regulation of the CFTR - generated chloride channel

D. P. Rich, J. Marshall, R. J. Gregory, M. J. Welsh, A. E. Smith
Journal of Clinical Investigation . • 1991
View 5 Excerpts
Highly Influenced

Adenosine diphosphate interfers with the ability of glyburide to block cardiac ATP - sensitive potassium channels

J. N. Weiss
Clinical Research . • 1991

CI - channel activity in Xenopus oocytes expressing the cystic fibrosis gene

C. Li, N. Kartner, +3 authors J. R. Riordan
Journal of Biological Chemistry . • 1991

Effect of deleting the R domain on CFFR - generated chloride channels

J. M. Rommens, B. Kerem, +6 authors J. L. Chou

Expression of the cystic fibrosis gene in non - epithelial invertebrate cells produces a regulated anion conductance

C. N. Hales, M. L. Ashford

Immunocytochemical localization of the cystic fibrosis gene product CFTR

L. S. Ostedgaard, S. H. Cheng, A. E. Smith, M. J. Welsh
Proceedings of the National Academy of Sciences , USA . • 1991