Effect of ATP depletion on kinetics of Na/Ca exchange-mediated Ca influx in Na-loaded heart cells.

@article{Haworth1997EffectOA,
  title={Effect of ATP depletion on kinetics of Na/Ca exchange-mediated Ca influx in Na-loaded heart cells.},
  author={Robert Haworth and Amy Biggs},
  journal={Journal of molecular and cellular cardiology},
  year={1997},
  volume={29 2},
  pages={503-14}
}
The kinetics of Ca influx by Na/Ca exchange into adult rat heart cells loaded with Na and depleted of ATP were investigated, to further elucidate how ATP regulates exchanger properties in the intact heart cell. We found an eight-fold reduction in Vmax for Ca uptake by ATP depletion, with no significant change in the K(m) for extracellular Ca or the K1 for inhibition by extracellular Na. Autoradiography of ATP depleted cells after45Ca uptake showed no gross heterogeneity of Ca uptake, as would… CONTINUE READING
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