Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.

@article{Drzezga2009EffectOA,
  title={Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.},
  author={Alexander Drzezga and Timo Grimmer and Gjermund Henriksen and Mark M{\"u}hlau and Robert Perneczky and Isabelle Miederer and Christine Praus and Christian Sorg and Afra M. Wohlschl{\"a}ger and Matthias Riemenschneider and Hans Juergen Wester and Hans F{\"o}rstl and Markus Schwaiger and Alexander Kurz},
  journal={Neurology},
  year={2009},
  volume={72 17},
  pages={1487-94}
}
OBJECTIVE To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo. METHODS Thirty-two patients with moderate AD were divided into carriers and noncarriers of the epsilon4 allele. These groups were matched for age, disease duration, education, and cognitive impairment. In all subjects, [11C]PIB-PET was performed for measurement of cerebral Abeta plaque deposition and cranial MRI for the assessment… CONTINUE READING

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