Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.

@article{Liu2010EffectOA,
  title={Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.},
  author={Yawu Liu and Teemu Paajanen and Eric Westman and Lars-Olof Wahlund and Andrew Simmons and Catherine Tunnard and Tomasz M Sob{\'o}w and Petroula Proitsi and John G. Powell and Patrizia Mecocci and Magda Tsolaki and Bruno Vellas and Sebastian Muehlboeck and Alan Evans and Christian Spenger and Simon Lovestone and Hilkka Soininen},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={21 3},
  pages={947-66}
}
The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer's disease (AD), but its effect on brain volumes is controversial. We explored the effect of the ε4 allele on regional cortical thickness and volume measurements using an automated pipeline in 111 subjects with mild cognitive impairment (MCI), 115 AD patients, and 107 age-matched healthy controls. The clinical data were used as covariates in the thickness and volume comparisons. The ε4 carriers had significantly smaller volume… CONTINUE READING

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