Effect of AD-5423 on animal models of schizophrenia: phencyclidine-induced behavioral changes in mice

@article{Nagai2003EffectOA,
  title={Effect of AD-5423 on animal models of schizophrenia: phencyclidine-induced behavioral changes in mice},
  author={Taku Nagai and Yukihiro Noda and Teruaki Une and Kiyoshi Furukawa and Hiroshi Furukawa and Quan Kan and Toshitaka Nabeshima},
  journal={NeuroReport},
  year={2003},
  volume={14},
  pages={269-272}
}
The antipsychotic efficacy of AD-5423, which has the properties of both a serotonin 5-HT2 and a dopamine D2 receptor antagonist, was evaluated using animal models of schizophrenia. Sensitization to phencyclidine (PCP)-induced hyperlocomotion is considered a model of the positive symptoms of schizophrenia, and was significantly antagonized by AD-5423 and haloperidol. The PCP-induced enhancement of immobility induced by the forced swimming test, a model of the negative symptoms of schizophrenia… 

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