Effect of ACE Inhibition on Spontaneous and Insulin-Stimulated Endothelin-1 Secretion: In Vitro and In Vivo Studies

@article{Desideri1997EffectOA,
  title={Effect of ACE Inhibition on Spontaneous and Insulin-Stimulated Endothelin-1 Secretion: In Vitro and In Vivo Studies},
  author={Giovambattista Desideri and Claudio Ferri and Cesare Bellini and Giancarlo De Mattia and Anna Santucci},
  journal={Diabetes},
  year={1997},
  volume={46},
  pages={81 - 86}
}
To evaluate the effect of angiotensin-converting inhibition enzyme on spontaneous and insulin-stimulated endothelin-1 (ET-1) secretion in vitro and in vivo, human endothelial cells derived from umbilical cord veins were cultured onto acellular collagen-coated permeable membrane, thus mimicking in vivo conditions with a luminal and abluminal side. Insulin (10−6,−8,−9 mol/l) significantly stimulated ET-1 secretion by cultured cells (P < 0.05 starting from 2-h incubation). Captopril (10−7,−8,−9… 
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