Corpus ID: 5798968

Effect of 9-benzyl-9-deazaguanine, a potent inhibitor of purine nucleoside phosphorylase, on the cytotoxicity and metabolism of 6-thio-2'-deoxyguanosine.

@article{Parker1994EffectO9,
  title={Effect of 9-benzyl-9-deazaguanine, a potent inhibitor of purine nucleoside phosphorylase, on the cytotoxicity and metabolism of 6-thio-2'-deoxyguanosine.},
  author={W. Parker and P. Allan and S. Niwas and J. Montgomery and L. Bennett},
  journal={Cancer research},
  year={1994},
  volume={54 7},
  pages={
          1742-5
        }
}
6-Thio-2'-deoxyguanosine (T-dGuo) has been reported to be both phosphorylated by deoxycytidine kinase and converted to 6-thioguanine by purine nucleoside phosphorylase (PNP). Combination of T-dGuo with an inhibitor of PNP would be expected to generate the 5'-triphosphate of T-dGuo and limit or prevent the formation of 6-thioguanosine triphosphate. Because the incorporation of 6-thioguanine into DNA is believed to be primarily responsible for the antitumor activity of the thiopurines, this… Expand
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References

SHOWING 1-10 OF 18 REFERENCES
METABOLISM OF PURINE NUCLEOSIDE ANALOGS.
Use of nucleosides in resistance to 6-thioguanine.
The utilization of alpha-2'-deoxythioguanosine by murine tumor cells.
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